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Application of formamide in fine chemical products


Formamide amino formaldehyde, also known as English name Formamide, molecular formula HCONH 2, the molecular weight of 5.04 d, for a similar glycerol of colorless, odorless have sour viscous liquid, the boiling point 210 ℃, the proportion of (d) 1.3340, soluble in water, methanol, ethanol, acetone, acetic acid and organic solvents.Formamide is a kind of simplest amide which is not only a basic organic chemical raw material, but also an important fine chemical raw material.The most important use of formamide is synthetic medicine.Second, used as dye, pigment intermediates and paper improvers.

1. Pharmaceutical industry

Formamide is the production of sulfonamides, vitamin B.Don't Piao alcohol, psoriasis, cholesterol-lowering drugs, new drugs such as medicine (1) one of the raw material of sulfonamides sulfanilamide methyl isopropyl pbo, also called the new north Ming or (sulfonated, English name SMZ, is a kind of effect of sulphonamide, wide antimicrobial spectrum, strong antibacterial effect, it is mainly used for respiratory tract infections and urinary tract infections in the synthesis of SMZ, intermediate of 4, 6 pair of hydroxy methoxy pyrimidine system by methoxy malonyl and formamide in the central, sodium methoxide.(2) the synthesis of vitamin B vitamin B4 a 6 also called Biao whisper of phosphate glands or krypton purine phosphate, can stimulate white blood cells proliferation effect, can be used in the treatment of various causes of white blood cells reduce disease, especially for swollen leukopenia caused by chemotherapy of disease.In the process of synthesizing B from diethyl malonate, formamide was used as the main material for the first and fifth steps of cyclization reaction.(3) synthesis of vitamin B6.Vitamin B6, also known as pyridoxine hydrochloride, is a co-enzyme of important enzymes in kryptonian acid metabolism, such as transaminase and amino acid decarboxylase.Used for prevention and control of the central nervous system symptoms of isoniazid and peripheral neuritis of side effects, and is used for the vomiting of pregnancy, radiation sickness or anticancer drugs, seborrheic dermatitis, pellagra and long-term oral broad-spectrum antibiotic index of vitamin deficiency in krypton acid synthesis of vitamin c a route of pbo, formamide as formylation reagent.(4) Ds ~ Na synthesis of lipid-lowering drugs.Dextran sulfuric acid ester (sodium salt)(DS - Na), used as a new drug to reduce blood lipids and prevent atherosclerosis caused by excessive blood lipids.The medicine was produced by the method of formamide - chlorosulfonic acid.(5) synthesis of allopurinol.Don't Piao alcohol and 4 hydroxy pyrazole (3, 4, d) pyrimidine, "clinical used in the treatment of various diseases of primary or secondary increased serum urine clear, for example, gout, acute or chronic disease of white, polycythemia vera, multiple myeloma and other malignant tumor during chemotherapy or radiotherapy cells necrosis caused by high uric acid hematic disease, prevention and treatment of uric acid nephropathy. In cyanoacetic acid synthetic process for raw material don't Piao alcohol the three steps of the reaction, formamide as intermediate raw material for the third step cyclization reaction. (6) imide 】 54 (] 54 (CRF).Amine ~] 54, also known as ethylenediamine tetraacetylamine.According to the report.The drug has obvious inhibitory effect on many experimental tumors.Clinical observation of this drug on gastric cancer, breast cancer, reticular cell sarcoma has a certain relief effect.In addition, this medicine has a good effect on the treatment of psoriasis.In the four-step process of synthesis of ethylenediamine tetraacetylamine from chloroacetic acid, formamide was used as the intermediate material for ring table reaction.(7) synthesis of other drugs.Methylamine can be catalyzed at high temperatures to produce hydrogen cyanide, which is used in the treatment of trichomoniasis, pyrimidine and 1,3,5 triazine.It is also used to produce coffee base, cocoa base and tea base.In order to make penicillin and dihydrostreptomycin sulfate crystallize, formamide is often used as solvent.

2. Dye and coating industries

Methylamide is used in the production of gold dye, azo dye and anthraquinone dye in plastic and cotton adhesive, coated with formamide.It can enhance the fastness of the sticky table.In the production of binder and paste.Formamide is used as a solvent for starch and casein.

3. Plastics industry

In the process of producing synthetic resin.Formamide is used as plasticizer, solvent stabilizer and dispersant.In the process of plastic production and processing, formamide is used for spinning acrylonitrile copolymer and making ion exchange resin by unsaturated amine polymerization.And with

Antistatic and conductive coatings for plastic products.

4. Fiber industry

In the process of fiber treatment, formamide is commonly used as fiber softener, temperature-regulating agent, anti-mildew agent, anti-shrinkage agent and antistatic agent.

5. Pesticide industry

Methylamide is one of the raw materials for producing 1,2,4, triazole intermediates.

6. Other applications

Formamide is also used to separate chlorosilane and purify oil.It is also widely used as a paper treatment agent and animal glue softener.

 
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